Lungkine (CXCL15), Murine Recombinant | P1296

Lungkine is a CXC chemokine that is expressed in lung epithelial cells and, to a lesser extent, in certain fetal tissues. No human homolog has been identified and a specific cell surface receptor has not yet been found. Lungkine expression in lung tissue is elevated in response to inflammation, at which time it acts to specifically recruit neutrophils and direct them into the lung airway. Recombinant murine Lungkine is a 16.3 kDa CXC chemokine consisting of 142 amino acid residues, including four conserved cysteine residues present in CXC chemokines.

P1296 | Lungkine CXCL15 Murine Recombinant DataSheet

Biomolecule/Target: Lungkine (CXCL15)

Synonyms: CXCL15, Lungkine, Small-inducible cytokine B15, Scyb15, Weche, C-X-C motif chemokine 15

Alternates names: IFN-b2, B cell differentiation factor, BCDF, BSF-2, HPGF, HSF, MGI-2, B-cell stimulatory factor 2, Interferon beta-2, Hybridoma growth factor, CTL differentiation factor, CDF, IL-6, HGF.

Taglines: N/A

NCBI Gene ID #: 3569

NCBI Gene Symbol: IL6

Gene Source: Human

Accession #: P05231

Recombinant: Yes

Source: HEK293 cells

Purity by SDS-PAGEs: > 90%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level:

Activity (Specifications/test method): TF-1 cells were stimulated with human recombinant IL-6 for 36 hrs and cell proliferation was measured using the Quick Cell Proliferation Colorimetric Assay Kit Plus (Cat. No. K302).

Biological activity: EC50 < 1 ng/mL

Results: EC50 <0.7 ng/mL

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: This protein is fused with polyhistidine tag at the C-terminus and has a calculated MW of 22.8 kDa (30-212aa). Under reducing conditions the protein migrates as ~23-29 kDa bands in SDS-PAGE.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4, with 0.02 % Tween-20.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water.

Amino acid sequence: N/A