LY-2157299 | 9475

LY-2157299 is a potent and selective TGFβ receptor I (TβRI) inhibitor (IC₅₀ = 56 nM). LY-2157299 abolishes the TGFβ induced Smad2 phosphorylation in HUVEC cells. It also shows dose dependent potentiation of VEGF or bFGF induced cell proliferation in HUVEC.

LY-2157299 is a potent and selective TGFβ receptor I (TβRI) inhibitor (IC₅₀ = 56 nM). LY-2157299 abolishes the TGFβ induced Smad2 phosphorylation in HUVEC cells. It also shows dose dependent potentiation of VEGF or bFGF induced cell proliferation in HUVEC.

9475 | LY-2157299 DataSheet

Alternate Name/Synonyms: 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide; Galunisertib

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 700874-72-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₂H₁₉N₅O

Molecular Weight: 369.42

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective TGFβ receptor I (TβRI) inhibitor

MDL Number: N/A

PubChem CID: 10090485

SMILES: CC1=CC=CC(=N1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N

InChi: InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)

InChi Key: IVRXNBXKWIJUQB-UHFFFAOYSA-N