Description
LY-2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC₅₀ of 2 nM and 10 nM, respectively. LY-2835219 inhibits the proliferation of Rb-positive tumor cells and demonstrates dose-dependent growth inhibition in ER+ breast cancer models.
LY-2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC₅₀ of 2 nM and 10 nM, respectively. LY-2835219 inhibits the proliferation of Rb-positive tumor cells and demonstrates dose-dependent growth inhibition in ER+ breast cancer models.
Alternate Name/Synonyms: N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine; Abemaciclib
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1231930-82-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₃₂F₂N₈.CH₄O₃S
Molecular Weight: 602.7
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>50 mg/ml) or H₂O (>60 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A potent and selective inhibitor of CDK4 and CDK6
MDL Number: N/A
PubChem CID: 71576678
SMILES: CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
InChi: InChI=1S/C27H32F2N8.CH4O3S/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26;1-5(2,3)4/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34);1H3,(H,2,3,4)
InChi Key: NCJPFQPEVDHJAZ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |