LYVE1 polyclonal Antibody | BS90816

LYVE1 polyclonal Antibody | BS90816 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC FC

Application Range: WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) is expressed on the cell surface as a protein that is reduced by glycosidase treatment. LYVE-1 is abundant in spleen, lymph node, heart, lung and fetal liver, and is less abundant in appendix, bone marrow, placenta, muscle and adult liver. Expression of LYVE-1 is largely restricted to endothelial cells lining lymphatic vessels and splenic sinusoidal endothelial cells. LYVE-1 binds to both soluble and immobilized hyaluronan (HA) with greater specificity than HCAM. Like HCAM, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike HCAM, the LYVE-1 molecule co-localizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE-1 is used as a marker to study tumor lymphangiogenesis, which is an important area of investigation.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: LYVE1 polyclonal Antibody detects endogenous levels of LYVE1 protein.

Molecular Weight: 35 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: LYVE-1, CRSBP-1, LYVE1, Cell surface retention sequence-binding protein 1, CRSBP 1, CRSBP-1, CRSBP1, extracellular link domain containing 1, extracellular link domain-containing 1, Extracellular link domain-containing protein 1, HAR, Hyaluronic acid receptor, Lymphatic endothelium specific hyaluronan receptor, lymphatic vessel endothelial hyaluronan receptor 1, Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE 1, LYVE-1, LYVE1, LYVE1, XLKD1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: