M6PR polyclonal Antibody | BS8108

M6PR polyclonal Antibody | BS8108 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IHC

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200

Background: CD-MPR (cation-dependent mannose-6-phosphate receptor) is an oligomeric transmembrane protein that plays a critical role in the intracellular delivery of phosphorylated lysosomal enzymes from the trans-Golgi network (TGN) . Intracellular trafficking of CD-MPR is mediated by sorting signals in its 67 amino acid cytoplasmic tail, which prevent it from entering the lysosome, where it would be degraded. CD-MPR is predominantly expressed in mouse testicular germ cells and shows differentiated expression during maturation of rat spermatozoa. Increased expression of CD-MPR in Alzheimer’s disease and the location of the CD-MPR gene next to a region on chromosome 12 which is possibly linked to the disease indicate that CD-MPR may play a role in Alzheimer’s disease.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: M6PR polyclonal Antibody detects endogenous levels of M6PR protein.

Molecular Weight: ~ 31 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-MPR; 46 kDa mannose 6-phosphate receptor; MPR 46;M6PR; MPR46; MPRD

Immunogen: Recombinant full length Human M6PR.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: