mAB-M | Mouse anti-human Abeta protein (3-10) region, oligomer-specific (clone 2D10, F6) | AS13 2716

mAB-M | Mouse anti-human Abeta protein (3-10) region, oligomer-specific (clone 2D10, F6) | AS13 2716 | Gentaur UK, US & Europe Distribution

Immunogen: synthetic peptide chosen from human Abeta protein (3-10) pregion, oligomer specific

Host: Mouse

Conjugation: N/A

Clonality: Monoclonal

Isotype: IgG1, kappa light chain, (clone number 2D10, F6)

Purity: Immunogen affinity purified serum in PBS pH 7.4.

Format: Lyophilized

Tested Application: Dot blot (Dot), ELISA (ELISA), Immunolocalization (IL)

Related Products: AS10 932| Amyloid beta oligomer-specific monoclonal antibody (OMAB) AS10 932B | Amyloid beta oligomer-specific monoclonal antibody (OMAB), BiotinylatedAS13 2715 | mAB-O oligomer-specific anti-abeta monoclonal antibody

Recommended Dilutions: 10 ug/ml (IL), 1-2 ug/ml (Dot), 2-4 ug/ml (ELISA capture)

Molecular weight: 4, 5 kDa

Confirmed Reactivity: Human

Predicted Reactivity: N/A

Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Additional Information: Due to location of antigen used to elicit this antibody in 3-10 region, it should bind to full length APP.

Background: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), a peptide of 39-42 amino acids generated in vivo by specific, proteolytic cleavage of the amyloid precursor protein. Recent findings however suggest that smaller oligomeric forms of Abeta, formed in parallel to the amyloid plaques, excert the predominant tissue damaging effect.Specific identification of the oligomeric forms is as a consequence of great interest. Based on a recently published technique a highly oligomer-specific antibody (mAB-M), targeting Abeta oligomers while omitting reactivity towards the monomeric and fibrillar counterpart, has been developed.

Reconstitution: For reconstitution add 50 µl of sterile water

Storage: For short time storage please add sodium azide and srote at +4°C.For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

TAIR Nnumbre: N/A

Category: Alzheimer's disease

Research Area: Pathlogy, Alzheimer's disease