Description
Madrasin is a potent and cell-permeable pre-mRNA splicing inhibitor. It interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.
Madrasin is a potent and cell-permeable pre-mRNA splicing inhibitor. It interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.
Alternate Name/Synonyms: 2-((7-Methoxy-4-methylquinazolin-2-yl)amino)-5,6-dimethylpyrimidin-4(3H)-one
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 374913-63-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₆H₁₇N₅O₂
Molecular Weight: 311.34
Cell-Permeable?: Yes
Purity: ≥97% by HPLC
Solubilities: DMSO (~ 1 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and cell-permeable pre-mRNA splicing inhibitor.
MDL Number: MFCD02233199
PubChem CID: 816255
SMILES: CC1=C(NC(=NC1=O)NC2=NC3=C(C=CC(=C3)OC)C(=N2)C)C
InChi: InChI=1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)
InChi Key: QQJIYKXTEMDJFM-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |