MAFA Polyclonal Antibody | E-AB-53394

MAFA Polyclonal Antibody | E-AB-53394 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: HMafA, Mafa, MAFA, Pancreatic beta cell specific transcriptional activator, Pancreatic beta-cell-specific transcriptional activator, RIPE3b1, Transcription factor MafA, Transcription factor RIPE3b1, v maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian), v maf musculoaponeurotic fibrosarcoma oncogene homolog A, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A

Application: WB, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling, Signal transduction

Background: Members of the Maf family of basic region/leucine zipper (bZIP) transcription factors affect transcription in either a positive or negative fashion, depending on their particular protein partner and the context of the target promoter. c-Maf (Maf-2) and the closely related family members.MAFA acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity.

Concentration: 1.2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human MAFA

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 37 kDa

Molecular Weight(Observed): Refer to figures