MAG polyclonal Antibody | BS60807

MAG polyclonal Antibody | BS60807 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Myelin-associated glycoprotein (MAG) is a nervous system cell-surface adhesion protein that is involved in linking myelinating glial cells to neuronal axons. MAG contains a sialic acid binding site and five IgG-like domains, thus identifying MAG as a member of a subgroup of the immunoglobulin superfamily. Like myelin, MAG inhibits axonal outgrowth and contributes to the inhibitory properties of myelin. Growth inhibition by MAG has been shown to be blocked when cerebellar neurons are pre-incubated with the neurotrophins BDNF or GDNF. It is suggested that this neurotrophin priming elevates cAMP and activates PKA.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MAG polyclonal Antibody detects endogenous levels of MAG protein.

Molecular Weight: ~ 100 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Myelin-associated glycoprotein; Siglec-4a; MAG; GMA

Immunogen: A synthetic peptide corresponding to residues in Human MAG

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A