MALT1 (N324) polyclonal Antibody | BS2534

MALT1 (N324) polyclonal Antibody | BS2534 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC IF

Application Range: IHC: 1:50~1:200 IF: 1:50~1:200

Background: Mucosa Associated Lymphoid Tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B-cell lymphomas. MALT1 encodes two Iglike C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18) (q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. The MALT1-API2 fusion protein activates NF-κB and creates a signaling pathway, which is influenced by this Bcl10-MALT1 complex. MALT1 mRNA is found in pre-B cells, mature B cells, and plasma cells.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MALT1 (N324) polyclonal Antibody detects endogenous levels of MALT1 protein.

Molecular Weight: ~ 92 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Mucosa-associated lymphoid tissue lymphoma translocation protein 1; MALT lymphoma-associated translocation; Paracaspase; MALT1; MLT

Immunogen: Synthetic peptide, corresponding to amino acids 295-340 of Human MALT1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: