Manumycin A | 2333

An antibiotic Isolated from Streptomyces parvulus. A Potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC₅₀ = 30 nM). Does not affect geranylgeranyltransferase (GGTase) (IC₅₀ = 180 µM). Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19 µM).µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras.

Manumycin A is a potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC₅₀ = 30 nM). Does not affect geranylgeranyltransferase (GGTase) (IC₅₀ = 180 µM).

2333 | Manumycin A DataSheet

Alternate Name/Synonyms: NSC-622141; UFC 1C

Appearance: Yellow to brown solid

Formulation: N/A

CAS Number: 52665-74-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₁H₃₈N₂O

Molecular Weight: 550.64

Cell-Permeable?: Yes

Purity: ≥96% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent rasfarnesyltransferase (FTase) inhibitor

MDL Number: MFCD00920782

PubChem CID: 6438330

SMILES: CCCCC(C)C=C(C)C=C(C)C(=O)NC1=CC(C2C(C1=O)O2)(C=CC=CC=CC(=O)NC3=C(CCC3=O)O)O

InChi: InChI=1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-,29-,31+/m1/s1

InChi Key: TWWQHCKLTXDWBD-MVTGTTCWSA-N