Description
An antibiotic Isolated from Streptomyces parvulus. A Potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC₅₀ = 30 nM). Does not affect geranylgeranyltransferase (GGTase) (IC₅₀ = 180 µM). Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19 µM).µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras.
Manumycin A is a potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC₅₀ = 30 nM). Does not affect geranylgeranyltransferase (GGTase) (IC₅₀ = 180 µM).
Alternate Name/Synonyms: NSC-622141; UFC 1C
Appearance: Yellow to brown solid
Formulation: N/A
CAS Number: 52665-74-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₁H₃₈N₂O
Molecular Weight: 550.64
Cell-Permeable?: Yes
Purity: ≥96% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent rasfarnesyltransferase (FTase) inhibitor
MDL Number: MFCD00920782
PubChem CID: 6438330
SMILES: CCCCC(C)C=C(C)C=C(C)C(=O)NC1=CC(C2C(C1=O)O2)(C=CC=CC=CC(=O)NC3=C(CCC3=O)O)O
InChi: InChI=1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-,29-,31+/m1/s1
InChi Key: TWWQHCKLTXDWBD-MVTGTTCWSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |