MAP2K2 (MEK2 ) monoclonal Antibody | MB63897

MAP2K2 (MEK2 ) monoclonal Antibody | MB63897 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat, Dog

Application: IF, WB

Application Range: WB 1:200~2000, IF 1:100

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: mitogen-activated protein kinase kinase 2

Molecular Weight: 44.2 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CFC4; MAPKK2; MEK2; MKK2; PRKMK2

Immunogen: Full length human recombinant protein of human MAP2K2 (NP_109587) produced in HEK293T cell.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A