MAP2K3 (MEK3) monoclonal Antibody | MB63898

MAP2K3 (MEK3) monoclonal Antibody | MB63898 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Monkey, Mouse, Rat, Dog

Application: IF, WB

Application Range: WB 1:200~2000, IF 1:100

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: mitogen-activated protein kinase kinase 3

Molecular Weight: 39.1 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: MAPKK3; MEK3; MKK3; PRKMK3; SAPKK-2; SAPKK2

Immunogen: Full length human recombinanat protein of human MAP2K3 (NP_659731) produced in HEK293T cell.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A