MAP3K7 monoclonal Antibody | MB63905

MAP3K7 monoclonal Antibody | MB63905 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Rat

Application: WB

Application Range: WB 1:2000

Background: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: mitogen-activated protein kinase kinase kinase 7

Molecular Weight: 64 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: MEKK7; TAK1; TGF1a

Immunogen: Human recombinant protein fragment corresponding to amino acids 254-367 of human MAP3K7 (NP_003179) produced in E.coli.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A