MAP3K8 monoclonal Antibody | MB63906

MAP3K8 monoclonal Antibody | MB63906 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: WB

Application Range: WB 1:500

Background: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: mitogen-activated protein kinase kinase kinase 8

Molecular Weight: 52.7 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: AURA2; c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2

Immunogen: Human recombinant protein fragment corresponding to amino acids 277-461 of human MAP3K8 (NP_005195) produced in E.coli.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A