Description
MAPK8 Polyclonal Antibody | E-AB-52157 | Gentaur UK, US & Europe Distribution
Type: Polyclonal Antibody
Synonyms: AI849689, c Jun N terminal kinase 1, C-JUN kinase 1, c-Jun N-terminal kinase 1, EC 2.7.11.24, JNK 1, JNK, JNK-46, JNK1A2, JNK21B1/2, MAP kinase 8, MAPK 8, mapk8, Mitogen activated protein kinase 8, Mitogen-activated protein kinase 8, MK08, p54 gamma, Prkm8, Protein kinase JNK1, Protein kinase, mitogen-activated, 8, SAPK 1, SAPK gamma, SAPK1, Stress-activated protein kinase 1, Stress-activated protein kinase JNK1
Application: WB, ELISA
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Immunology, Signal Transduction
Background: MAPK8(Mitogen-activated protein kinase 8) is also named as JNK1, PRKM8, SAPK1, SAPK1C and belongs to the MAP kinase subfamily. MAPK8 is activated by dual phosphorylation at a Thr-Pro-Tyr motif during response to UV light. MAPK8 functions to phosphorylate c-Jun at N-terminal serine regulatory sites of Ser-63 and Ser-73, mapping within the transactivation domain. Phosphorylation of these sites in response to UV results in transcriptional activation of c-Jun. It has 4 isoforms produced by alternative splicing with the molecular weight of 46 kDa and 48 kDa. This protein can be phosphorylated and this antibody recognizes the 46 kDa and 55 kDa bands in western blot.
Concentration: 1.9 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Fusion protein of human MAPK8
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method: Antigen affinity purification
Dilution: WB 1:1000-1:5000, ELISA 1:2000-1:10000
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 48 kDa
Molecular Weight(Observed): Refer to figures