MAPK9 Antibody, KO Validated | 14-471

MAPK9 Antibody, KO Validated | 14-471 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-424 of human MAPK9 (NP_002743.3) .

Research Area: Apoptosis, Cancer, Cell Cycle, Immunology, Innate Immunity, Neuroscience, Signal Transduction

Tested Application: WB, IHC, IF

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200

Specificiy: N/A

Positive Control 1: MCF-7

Positive Control 2: DU145

Positive Control 3: THP-1

Positive Control 4: Mouse liver

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 54kDa

Validation: Antibody is Knockout validated.

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: MAPK9, stress-activated protein kinase JNK2, SAPK, PRKM9, p54aSAPK, p54a, OTTHUMP00000161543, OTTHUMP00000161542, mitogen-activated protein kinase 9, MAPK 9, MAP kinase 9, Jun kinase, JNK-55, JNK2BETA, JNK2B, JNK2ALPHA, JNK2A, JNK2, c-Jun N-terminal kinase 2, c-Jun kinase 2, SAPK1A

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.