Mapracorat | B3078

Mapracorat is a selective glucocorticoid receptor agonist (SEGRA) with anti-inflammatory properties. It is in clinical trials for the topical treatment of atopic dermatitis, allergic conjunctivitis and Eczema. It inhibits TNFα secretion from activated canine peripheral blood derived mononuclear cells with an IC₅₀ value of approximately 0.2 nM. It shows beneficial effects in inflammatory and pruritic skin diseases in dogs.

Mapracorat is a selective glucocorticoid receptor agonist (SEGRA) with anti-inflammatory properties. It is in clinical trials for the topical treatment of atopic dermatitis, allergic conjunctivitis and Eczema. It inhibits TNFα secretion from activated canine peripheral blood derived mononuclear cells with an IC₅₀ value of approximately 0.2 nM. It shows beneficial effects in inflammatory and pruritic skin diseases in dogs.

B3078 | Mapracorat DataSheet

Alternate Name/Synonyms: BOL-303242X; ZK-245186; (2R)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-ol; 7-Benzofuranpropanol, 5-fluoro-2,3-dihydro-gamma,gamma-dimethyl-alpha-(((2-methyl-5-quinolinyl)amino)methyl)-alpha-(trifluoromethyl)-, (alphaR)-

Appearance: Yellow crystals

Formulation:

CAS Number: 887375-26-0

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₅H₂₆F₄N₂O₂

Molecular Weight: 462.49

Cell-Permeable?: TRUE

Purity: >98%

Solubilities: ~33 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: a selective glucocorticoid receptor agonist

MDL Number: MFCD19443722

PubChem CID: 24795088

SMILES: CC1=NC2=C(C=C1)C(=CC=C2)NCC(CC(C)(C)C3=CC(=CC4=C3OCC4)F)(C(F)(F)F)O

InChi: InChI=1S/C25H26F4N2O2/c1-15-7-8-18-20(5-4-6-21(18)31-15)30-14-24(32,25(27,28)29)13-23(2,3)19-12-17(26)11-16-9-10-33-22(16)19/h4-8,11-12,30,32H,9-10,13-14H2,1-3H3/t24-/m1/s1

InChi Key: VJGFOYBQOIPQFY-XMMPIXPASA-N