MARS polyclonal Antibody | BS71376

MARS polyclonal Antibody | BS71376 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB

Application Range: WB 1:500 - 1:2000

Background: MARS2 (methionyl-tRNA synthetase 2, mitochondrial), also known as MetRS or MtMetRS, is a 593 amino acid mitochondrial matrix protein that belongs to the class-I aminoacyl-tRNA synthetase family. MARS2 functions at an optimal pH of 7.8 to 8.2 and contains HIGH and KMSKS motifs, both of which are signature sequences found in all class I synthetases. The gene encoding MARS2 maps to human chromosome 2q33.1. Consisting of of 237 million bases and encoding over 1,400 genes, chromosome 2 is the second largest human chromosome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MARS polyclonal Antibody detects endogenous levels of MARS protein.

Molecular Weight: ~ 110 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Methionyl-tRNA synthetase; MetRS

Immunogen: Recombinant protein of human MARS.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: