Massonianoside B | B2537

Massonianoside B (MA) is a structurally unique natural product inhibitor of DOT1L with an IC50 value of 399 nM. It displays high selectivity for DOT1L over other S-adenosylmethionine (SAM)-dependent PMTs (Protein methyltransferases).

Massonianoside B (MA) is a structurally unique natural product inhibitor of DOT1L with an IC50 value of 399 nM. It displays high selectivity for DOT1L over other S-adenosylmethionine (SAM)-dependent PMTs (Protein methyltransferases).

B2537 | Massonianoside B DataSheet

Alternate Name/Synonyms: MA; (2S,3R,4R,5R,6S)-2-[4-[(2S,3R)-7-hydroxy-3-(hydroxymethyl)-5-(3-hydroxypropyl)-2,3-dihydro-1-benzofuran-2-yl]-2-methoxyphenoxy]-6-methyloxane-3,4,5-triol

Appearance: Lyophilized solid

Formulation:

CAS Number: 188300-19-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₂O₁₀

Molecular Weight: 492.52

Cell-Permeable?: True

Purity: ≥95%

Solubilities: in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective DOT1L inhibitor

MDL Number: MFCD20274727

PubChem CID: 76311962

SMILES: CC1C(C(C(C(O1)OC2=C(C=C(C=C2)C3C(C4=CC(=CC(=C4O3)O)CCCO)CO)OC)O)O)O

InChi: InChI=1S/C25H32O10/c1-12-20(29)21(30)22(31)25(33-12)34-18-6-5-14(10-19(18)32-2)23-16(11-27)15-8-13(4-3-7-26)9-17(28)24(15)35-23/h5-6,8-10,12,16,20-23,25-31H,3-4,7,11H2,1-2H3/t12-,16-,20-,21+,22+,23+,25-/m0/s1

InChi Key: PHHIEOZUONPPQY-ROQFLNLZSA-N