BW
MB21D1 polyclonal Antibody | BS71168
- SKU:
- BW-BS71168
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Description
MB21D1 polyclonal Antibody | BS71168 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human
Application: WB
Application Range: WB :1:500~1:2000
Background: cGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MB21D1 polyclonal Antibody detects endogenous levels of MB21D1 protein.
Molecular Weight: ~ 59 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: cGAS; h-cGAS; C6orf150
Immunogen: A synthetic peptide of human MB21D1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: