MBD3 Antibody (C-term) [APR30597G]

MBD3 Antibody (C-term) [APR30597G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This MBD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-291 amino acids from the C-terminal region of human MBD3.

Cellular Localisation: Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes

Molecular Weight: 32844

Clone: Polyclonal

Gene Name: MBD3

Gene ID: 53615

Function: Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384) . Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro) . Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175) . Recruits histone deacetylases and DNA methyltransferases.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Methyl-CpG-binding domain protein 3, Methyl-CpG-binding protein MBD3, MBD3