MBTPS2 Polyclonal Antibody | E-AB-52057

MBTPS2 Polyclonal Antibody | E-AB-52057 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: BRESEK, Endopeptidase S2P, IFAP, KFSDX, MBTP2, MBTPS2, Membrane bound transcription factor site 2 protease, membrane-bound transcription factor peptidase, site 2, membrane-bound transcription factor protease, site 2, Membrane-bound transcription factor site-2 protease, S2P, S2P endopeptidase, Site 2 protease, SREBPs intramembrane protease, Sterol regulatory element-binding proteins intramembrane protease

Application: WB, IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cell Biology, Cardiovascular, Metabolism, Signal transduction

Background: This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

Concentration: 0.9 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human MBTPS2

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:10-1:50, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 57 kDa

Molecular Weight(Observed): Refer to figures