MCA1 Antibody (C-term) [APR05798G]

MCA1 Antibody (C-term) [APR05798G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This MCA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-268 amino acids from the C-terminal region of human MCA1.

Cellular Localisation: Nucleus. Cytoplasm, cytosol. Secreted. Endoplasmic reticulum {ECO:0000250|UniProtKB:P31230}. Golgi apparatus {ECO:0000250|UniProtKB:P31230}. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity) . Secreted in response to hypoxia (PubMed:10850427) . Also secreted in response to both apoptotic and necrotic cell death. {ECO:0000250|UniProtKB:P31230, ECO:0000269|PubMed:10850427}

Molecular Weight: 34353

Clone: Polyclonal

Gene Name: AIMP1

Gene ID: 9255

Function: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004) . Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575) . Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7- mediated degradation (By similarity) . Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity) . Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771) . Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity) . Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313) . Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442) . Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide 2, EMAP-2, Endothelial monocyte-activating polypeptide II, EMAP-II, Small inducible cytokine subfamily E member 1, AIMP1, EMAP2, SCYE1