MCC950 sodium | 9686

MCC950 sodium is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Also glutathione S-transferase omega 1 inhibitor. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.

MCC950 sodium is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Also glutathione S-transferase omega 1 inhibitor. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.

9686 | MCC950 sodium DataSheet

Alternate Name/Synonyms: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt; CP-456,773; CRID3

Appearance: Off-white solid

Formulation: N/A

CAS Number: 256373-96-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₃N₂NaO₅S

Molecular Weight: 426.46

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>35 mg/ml) or H2O (>30 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent and selective NLRP3 inflammasome inhibitor

MDL Number: N/A

PubChem CID: 91826093

SMILES: CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]

InChi: InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1

InChi Key: LFQQNXFKPNZRFT-UHFFFAOYSA-M