MCM3 Polyclonal Antibody | E-AB-40230

MCM3 Polyclonal Antibody | E-AB-40230 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Cervical cancer proto oncogene 5, DNA polymerase alpha holoenzyme associated P1, HCC 5, HCC5, hRlf beta subunit, Human cervical cancer proto oncogene 5, MCM 3, MGC1157, Minichromosome maintenance complex component 3, P1 h, P1 MCM3, P1.h, p102, Replication licensing factor beta subunit, RLF beta subunit, RLFB

Application: WB, IHC

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with mCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.

Concentration: 2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Human DNA replication licensing factor MCM3 protien

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A