MCM5 polyclonal Antibody | BS90832

MCM5 polyclonal Antibody | BS90832 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB IHC

Application Range: WB:1:500-1:1,000 IHC:1:50-1:200

Background: The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation during apoptosis of the MCM complex, which is composed of, at least, MCM2–6.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: MCM5 polyclonal Antibody detects endogenous levels of MCM5 protein.

Molecular Weight: 82 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: MCM5, CDC46, CDC 46, CDC46, CDC46 homolog, Cell division cycle 46, DNA replication licensing factor, DNA replication licensing factor MCM 5, DNA replication licensing factor MCM5, MCM 5, MCM5, MCM5, MGC5315, Minichromosome maintenance complex component 5, Minichromosome maintenance deficient (S. cerevisiae) 5, Minichromosome maintenance deficient 5, Minichromosome maintenance deficient protein 5, P1 CDC46, P1-CDC46,

Immunogen: Recombinant protein within C terminal human MCM5.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: