MCM7 Antibody| F44682-0.08ML/F44682-0.4ML/R30051/V3365-20UG/V3501IHC-7ML

MCM7 Antibody| F44682-0.08ML/F44682-0.4ML/R30051/V3365-20UG/V3501IHC-7ML | Gentaur UK, US & Europe Distribution

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the MCM7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This MCM7 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 290-318 from the human protein was used as the immunogen for this MCM7 antibody.

Storage: Aliquot the MCM7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A