Description
MCM7 polyclonal Antibody | BS6169 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse
Application: WB IF
Application Range: WB: 1:500~1:2000 IF: 1:50~1:200
Background: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MCM7 polyclonal Antibody detects endogenous levels of MCM7 protein.
Molecular Weight: ~ 91 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: DNA replication licensing factor MCM7; CDC47 homolog; P1.1-MCM3; MCM7; CDC47; MCM2
Immunogen: Recombinant full length Human MCM7.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Regulation of Microtubule Dynamics,B cell receptor signaling,