MCP-1 Antibody [1A7B8] | 32-230

MCP-1 Antibody [1A7B8] | 32-230 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: Ni-NTA purified recombinant human MCP-1 expressed in E.Coli strain BL21 (DE3) .

Research Area: Innate Immunity

Tested Application: E, WB

Application: Western Blot:1:500 - 1, 000
ELISA:1, 000 - 2, 000.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: Antibody is purified by protein A affinity chromatography.

Clonality: Monoclonal

Clone: 1A7B8

Isotype: IgG1.kappa

Conjugate: Unconjugated

Physical State: N/A

Buffer: Purified antibody in PBS containing 0.03% sodium azide.

Concentration: N/A

Storage Condition: to MCP-1 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: MCP1, SCYA2, HC11, MCAF, MCP1, MCP-1, GDCF-2, SMC-CF, HSMCR30

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH) . Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.