MCU polyclonal Antibody | BS90834

MCU polyclonal Antibody | BS90834 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB ICC IHC FC

Application Range: WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex. Activity is regulated by MICU1 and MICU2. At low Ca2+ levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca2+ levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: MCU polyclonal Antibody detects endogenous levels of MCU protein.

Molecular Weight: Predicted band size 40 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: HsMCU, MCU, C10orf42, CCDC109A, C109A, C10orf42, Calcium uniporter protein mitochondrial, Ccdc109a, Coiled-coil domain-containing protein 109A, HsMCU, Mitochondrial Calcium Uniporter,

Immunogen: Recombinant protein within human MCU aa 50-250.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein affinity purified.

Pathway: