MDFI (P134) polyclonal Antibody | BS3882

MDFI (P134) polyclonal Antibody | BS3882 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: MDFI is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. MDFI an also interfere with the DNA-binding activity of Myod family members and plays an important role in trophoblast and chondrogenic differentiation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MDFI (P134) polyclonal Antibody detects endogenous levels of MDFI protein.

Molecular Weight: ~ 25 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: MyoD family inhibitor; Myogenic repressor I-mf; MDFI

Immunogen: Synthetic peptide, corresponding to amino acids 100-146 of Human MDFI.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: