Description
ME-0328 is a potent and selective PARP-3 inhibitor (IC₅₀ = 0.89 µM). ME-0328 inhibits PARP-1, PARP-2 and other ARDTs (ADP ribosyltransferases) at much higher concentrations (IC₅₀ = 6.3, 10.8 and >30 µM, respectively).
ME-0328 is a potent and selective PARP-3 inhibitor (IC₅₀ = 0.89 µM). ME-0328 inhibits PARP-1, PARP-2 and other ARDTs (ADP ribosyltransferases) at much higher concentrations (IC₅₀ = 6.3, 10.8 and >30 µM, respectively).
Alternate Name/Synonyms: 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
Appearance: White solid
Formulation: N/A
CAS Number: 1445251-22-8
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₉N₃O₂
Molecular Weight: 321.37
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (~30 mg/ml) or EtOH (~4 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent PARP-3 inhibitor
MDL Number: N/A
PubChem CID: 71571526
SMILES: CC(C1=CC=CC=C1)NC(=O)CCC2=NC(=O)C3=CC=CC=C3N2
InChi: InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1
InChi Key: QIHBWVVVRYYYRO-ZDUSSCGKSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |