ME-0328 | 2751

ME-0328 is a potent and selective PARP-3 inhibitor (IC₅₀ = 0.89 µM). ME-0328 inhibits PARP-1, PARP-2 and other ARDTs (ADP ribosyltransferases) at much higher concentrations (IC₅₀ = 6.3, 10.8 and >30 µM, respectively).

ME-0328 is a potent and selective PARP-3 inhibitor (IC₅₀ = 0.89 µM). ME-0328 inhibits PARP-1, PARP-2 and other ARDTs (ADP ribosyltransferases) at much higher concentrations (IC₅₀ = 6.3, 10.8 and >30 µM, respectively).

2751 | ME-0328 DataSheet

Alternate Name/Synonyms: 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide

Appearance: White solid

Formulation: N/A

CAS Number: 1445251-22-8

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₉N₃O₂

Molecular Weight: 321.37

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~30 mg/ml) or EtOH (~4 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent PARP-3 inhibitor

MDL Number: N/A

PubChem CID: 71571526

SMILES: CC(C1=CC=CC=C1)NC(=O)CCC2=NC(=O)C3=CC=CC=C3N2

InChi: InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1

InChi Key: QIHBWVVVRYYYRO-ZDUSSCGKSA-N