ME3 (R576) polyclonal Antibody | BS3339

ME3 (R576) polyclonal Antibody | BS3339 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: ME3 (malic enzyme 3), also known as NADP-ME (NADP-dependent malic enzyme, mitochondrial), is a 604 amino acid protein of the mitochondrial matrix that catalyzes the conversion of (S) -malate and NADP+ to pyruvate, carbon dioxide and NADPH. A member of the malic enzymes family, ME3 utilizes manganese and magnesium as cofactors and is expressed in tissues that divide at a low rate. The gene encoding ME3 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ME3 (R576) polyclonal Antibody detects endogenous levels of ME3 protein.

Molecular Weight: ~ 67 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NADP-dependent malic enzyme, mitochondrial; NADP-ME; Malic enzyme 3; ME3

Immunogen: Synthetic peptide, corresponding to amino acids 547-598 of Human ME3.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: