MECP2 Antibody | XW-7368

MECP2 Antibody | XW-7368 | Gentaur UK, US & Europe Distribution

Host: Chicken

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: 170-486

Research Area: Homeostasis, Neuroscience

Tested Application: WB

Application: MeCP2 antibody can be used for the detection of MeCP2 by Western blot, may also work for IHC and ICC.

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 52.4 kDa (calculated)

Validation: N/A

Isoform: N/A

Purification: Antigen affinity-purified

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Phosphate-Buffered Saline. No preservatives added.

Concentration: 1 mg/mL

Storage Condition: MECP2 antibody can be stored at 4˚C for short term (weeks) . Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: Methyl-CpG-binding protein 2MeCp-2 protein, RS, RTS, RTT, PPMX, MRX16, MRX79, MRXSL, AUTSX3, MRXS13,

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Methyl CpG binding protein 2 (Rett syndrome) . DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD) . Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.