MEF2A (Acetyl-K403) polyclonal Antibody | BS64105

MEF2A (Acetyl-K403) polyclonal Antibody | BS64105 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: MEF2A is a member of the MEF2 (myocyte enhancer factor 2) family of transcription factors. In mammals, four MEF2A-related genes (MEF2A, MEF2B, MEF2C and MEF2D) encode proteins which exhibit significant amino acid sequence similarity within their DNA binding domains and to a lesser extent throughout the remaining proteins. The MEF2 family members were originally described as muscle-specific DNA binding proteins that recognize MEF2 motifs found within the promoters of many muscle-specific genes. Phosphorylation of MEF2A at Thr312 and Thr319 within the transcription activation domain by p38 MAP kinase enhances MEF2A-MEF2D heterodimer-dependent gene expression. On the other hand, apoptotic stimuli (e.g. neurotoxic insult) result in CDK5-dependent phosphorylation of MEF2A at Ser408 within the activation domain, inhibiting MEF2A pro-survival function.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MEF2A (Acetyl- -K403) polyclonal Antibody detects endogenous levels of MEF-2 protein only when acetylated at Lys403.

Molecular Weight: ~ 54 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1; MEF2A; MEF2

Immunogen: Synthetic Acetylated peptide derived from human MEF2A around the acetylation site of lysine 403.

Conjugate: Unconjugated

Modification: Acetylated

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE) .

Pathway: Regulation of Actin Dynamics,SAPK JNK Signaling Cascades,Contribution of ECM and Cytoskeletal Factors to EMT,