Meisoindigo | B1822

Meisoindigo is a synthetic derivative of indirubin that acts as a potential agent for acute myeloid leukemia. In the in vitro assay, it can inhibit synthesis of DNA and RNA and the assembly of microtubules. It is also reported to have efficacy in acute myeloid leukemia. In the AML cell lines, HL-60, NB4 and U937, meisoindigo induces apoptosis in both caspase-dependent and -independent pathways.

Meisoindigo is a synthetic derivative of indirubin that acts as a potential agent for acute myeloid leukemia. In the in vitro assay, it can inhibit synthesis of DNA and RNA and the assembly of microtubules. It is also reported to have efficacy in acute myeloid leukemia. In the AML cell lines, HL-60, NB4 and U937, meisoindigo induces apoptosis in both caspase-dependent and -independent pathways.

B1822 | Meisoindigo DataSheet

Alternate Name/Synonyms: (E)-1,1'-dimethyl-[3,3'-biindolinylidene]-2,2'-dione; Methyl isoindigotin; N-Methylisoindigotin; Meisoindigo; Dian III

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 97207-47-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₇H₁₂N₂O₂

Molecular Weight: 276.29

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An anticancer agent

MDL Number: N/A

PubChem CID: 5479433

SMILES: CN1C2=CC=CC=C2C(=C3C4=CC=CC=C4NC3=O)C1=O

InChi: InChI=1S/C17H12N2O2/c1-19-13-9-5-3-7-11(13)15(17(19)21)14-10-6-2-4-8-12(10)18-16(14)20/h2-9H,1H3,(H,18,20)/b15-14+

InChi Key: QNOCRUSVMMAKSC-CCEZHUSRSA-N