MEK-162 | 2254

Cell-permeable. A potent, non-ATP competitive inhibitor of MEK1/2 (IC₅₀ = 12 nM) and cellular pERK (IC₅₀ = 11 nM). Selective against a panel of other 220 kinases (displays no activity even at 10 µM).

MEK-162 is a potent, non-ATP competitive inhibitor of MEK1/2 (IC₅₀ = 12 nM) and cellular pERK (IC₅₀ = 11 nM).

2254 | MEK-162 DataSheet

Alternate Name/Synonyms: 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide; methyl-1H-benzimidazole-6-carboxamide; ARRY

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 606143-89-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₅BrF₂N₄O₃

Molecular Weight: 441.23

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~100 mM)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent and selective MEK1/2 inhibitor

MDL Number: N/A

PubChem CID: 10288191

SMILES: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO

InChi: InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChi Key: ACWZRVQXLIRSDF-UHFFFAOYSA-N