MEOX2 Antibody (Center) [APR31672G]

MEOX2 Antibody (Center) [APR31672G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This MEOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-192 amino acids from the Central region of human MEOX2.

Cellular Localisation: Nucleus. Nucleus speckle

Molecular Weight: 33594

Clone: Polyclonal

Gene Name: MEOX2 {ECO:0000303|PubMed:16335786, ECO:0000312|HGNC:HGNC:7014}

Gene ID: 4223

Function: Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity) . Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity) . May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity) . Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000) . Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000) . While it activates CDKN1A in a DNA- dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000) . Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P-Leica, IF, WB

Dilution: IF--1:10~50 WB--1:1000

Synonyms: Homeobox protein MOX-2, Growth arrest-specific homeobox, Mesenchyme homeobox 2, MEOX2, GAX, MOX2