Description
METAP2 Polyclonal Antibody | E-AB-62370 | Gentaur UK, US & Europe Distribution
Type: Polyclonal Antibody
Synonyms: METAP2, MAP2, MNPEP, p67eIF2
Application: WB
Reactivity: Human, Mouse
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Metabolism, Signal Transduction
Background: The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene.
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant fusion protein of human METAP2 (NP_006829.1).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification Method: Affinity purification
Dilution: WB 1:200-1:2000
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 50 kDa/52 kDa
Molecular Weight(Observed): 60 kDa