Metergoline | B3088

Metergoline is a serotonin (5-HT) receptor antagonist. It is active at 5-HT1 (pKi=7.8 for 5-HT1B), 5-HT2 (pKi=8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C respectively) and 5-HT7 (pKi=16 nM) receptor subtypes. Metergoline potently inhibits 5-HT radiolabeling of the human 5-hydroxytryptamine(7) receptor, with an IC₅₀ value of 73 nM. It inhibits 5-HT7 receptor-stimulated cAMP production with an IC₅₀ of 321 nM in HEK293 cells.

Metergoline is a serotonin (5-HT) receptor antagonist. It is active at 5-HT1 (pKi=7.8 for 5-HT1B), 5-HT2 (pKi=8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C respectively) and 5-HT7 (pKi=16 nM) receptor subtypes. Metergoline potently inhibits 5-HT radiolabeling of the human 5-hydroxytryptamine(7) receptor, with an IC₅₀ value of 73 nM. It inhibits 5-HT7 receptor-stimulated cAMP production with an IC₅₀ of 321 nM in HEK293 cells.

B3088 | Metergoline DataSheet

Alternate Name/Synonyms: Liserdol; benzyl N-[[(6aR,9S,10aR)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinolin-9-yl]methyl]carbamate; (((8-beta)-1,6-Dimethylergolin-8-yl)methyl)carbamic acid benzyl ester; (((8-beta)-1,6-Dimethylergolin-8-yl)methyl)carbamic acid phenylmethyl ester

Appearance: White to pale yellow powder

Formulation:

CAS Number: 17692-51-2

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₅H₂₉N₃O₂

Molecular Weight: 403.5

Cell-Permeable?: True

Purity: ≥ 98%

Solubilities: ~5 mg/ml in ethanol, ~30 mg/ml in DMF, ~25 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A serotonin (5-HT) receptor antagonist

MDL Number: MFCD00153829

PubChem CID: 28693

SMILES: CN1CC(CC2C1CC3=CN(C4=CC=CC2=C34)C)CNC(=O)OCC5=CC=CC=C5

InChi: InChI=1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1

InChi Key: WZHJKEUHNJHDLS-QTGUNEKASA-N