METTL7B polyclonal Antibody | BS8770

METTL7B polyclonal Antibody | BS8770 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: METTL7B (methyltransferase-like protein 7B) is a 244 amino acid protein belonging to the methyltransferase superfamily. METTL7B is believed to have methyltransferase activity, wherein METTL7B catalyzes the transfer of a methyl group from one compound to another. The gene that encodes METTL7B maps to chromosome 12 which makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: METTL7B polyclonal Antibody detects endogenous levels of METTL7B protein.

Molecular Weight: ~ 28kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Methyltransferase-like protein 7B; METTL7B; UNQ594/PRO1180

Immunogen: Recombinant full length Human METTL7B.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A