MFN1 Antibody (Center) [APR08438G]

MFN1 Antibody (Center) [APR08438G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This MFN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-381 amino acids from the Central region of human MFN1.

Cellular Localisation: Mitochondrion outer membrane; Multi-pass membrane protein

Molecular Weight: 84160

Clone: Polyclonal

Gene Name: MFN1

Gene ID: 55669

Function: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303) . Membrane clustering requires GTPase activity (PubMed:27920125) . It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303) . Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376) . Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376) . Has low GTPase activity (PubMed:27920125, PubMed:28114303) .

Summary: Tissue Location: Detected in kidney and heart (at protein level) (PubMed:12759376) . Ubiquitous (PubMed:11950885, PubMed:12759376) Expressed at slightly higher level in kidney and heart (PubMed:12759376) . Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Mitofusin-1, 365-, Fzo homolog, Transmembrane GTPase MFN1, MFN1