mGluR-6 (A865) polyclonal Antibody | BS1146

mGluR-6 (A865) polyclonal Antibody | BS1146 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: The mGluR proteins (metabotropic glutamate receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors) . The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR-1 and mGluR-5 are mediated by a G protein that activates a phosphatidylinositolcalcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight subtypes of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-6 is expressed in the synapses of bipolar cell dendrites. This receptor is involved in mediating synaptic transmission from rod and cone photoreceptors to other neurons.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: mGluR6 (A865) polyclonal Antibody detects endogenous levels of mGluR6 protein.

Molecular Weight: ~ 100 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Metabotropic glutamate receptor 6; mGluR6; GRM6; GPRC1F; MGLUR6

Immunogen: Synthetic peptide, corresponding to amino acids 841-890 of Human mGluR-6.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Regulation of Actin Dynamics,Insulin &Glucose Signaling,