MGP Polyclonal Antibody | E-AB-18763

MGP Polyclonal Antibody | E-AB-18763 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Cell growth inhibiting gene 36 protein, Cell growth-inhibiting gene 36 protein, GAMMA-CARBOXYGLUTAMIC ACID PROTEIN, MATRIX, GIG36, Matrix Gla protein, MGLAP, MGP, MGP, NTI

Application: IHC, ELISA

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Signal Transduction

Background: Matrix Gla protein (MGP) is is a vitamin K-dependent, extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.

Concentration: 1.32 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Fusion protein of human MGP

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:70-1:350, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A