Description
MI-2 is a Menin-MLL (Mixed linage leukemia) protein interaction inhibitor with an IC₅₀ of 0.45 μM. MLL protein is a histone methyltransferase that positively regulates gene transcription. However, MLL gene is a common target for chromosomal translocations found in some leukemia.
MI-2 is a Menin-MLL (Mixed linage leukemia) protein interaction inhibitor with an IC₅₀ of 0.45 μM. MLL protein is a histone methyltransferase that positively regulates gene transcription. However, MLL gene is a common target for chromosomal translocations found in some leukemia.
Alternate Name/Synonyms: 4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine; Menin-MLL inhibitor 2
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1271738-62-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₈H₂₅N₅S₂
Molecular Weight: 375.55
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>15 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A Menin-MLL (Mixed linage leukemia) protein interaction inhibitor
MDL Number: N/A
PubChem CID: 54765302
SMILES: CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(S4)(C)C
InChi: InChI=1S/C18H25N5S2/c1-4-5-13-10-14-15(20-12-21-16(14)24-13)22-6-8-23(9-7-22)17-19-11-18(2,3)25-17/h10,12H,4-9,11H2,1-3H3
InChi Key: SRQYLNYQAPCPIR-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |