MIF-Antagonist, ISO-1 | 1895

Cell-permeable. A macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity. Also inhibits tumor necrosis factor (TNF) release from macrophages isolated from LPS- treated wild type mice but has no effect on cytokine release from MIF deficient macrophages.

MIF-Antagonist, ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity.

1895 | MIF-Antagonist, ISO-1 DataSheet

Alternate Name/Synonyms: (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester

Appearance: Off-white solid

Formulation: N/A

CAS Number: 478336-92-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₁₃NO₄

Molecular Weight: 235.24

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A migration inhibitory factor (MIF) antagonist

MDL Number: MFCD22376813

PubChem CID: 6098948

SMILES: COC(=O)CC1CC(=C2C=CC(=O)C=C2)NO1

InChi: InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,13H,6-7H2,1H3

InChi Key: CLVQGFPQFNASJH-UHFFFAOYSA-N