MIP-1/CCL3, human recombinant | 7173

Both MIP-1 and MIP-1 are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 and MIP-1 exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 selectively attracting CD8+ lymphocytes and MIP-1 selectively attracting CD4+ lymphocytes. Additionally, MIP-1 and MIP-1 have also been shown to be potent chemo attractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 and MIP-1 are active on human and murine hematopoietic cells. Recombinant human MIP-1 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

7173 | MIP-1/CCL3 human recombinant DataSheet

Biomolecule/Target: CCL3

Synonyms: Macrophage Inflammatory Protein-1, CCL3, LD78

Alternates names:

Taglines: Participates in the host response to invading bacterial, viral, parasite and fungal pathogens

NCBI Gene ID #: 6233

NCBI Gene Symbol: RPS27A

Gene Source: Human

Accession #: P62979

Recombinant: Yes

Source: E. Coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 8.760 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.

Reconstitution Instructions: N/A

Amino acid sequence: N/A